Think about the evolutionary logics and you will comprehend the outcome of this immune escape pandemic…

The virus currently relies on the mobility of asymptomatically or mildly infected Covid-19 vaccinees for inter-host transmission. However, as circulating variants become more infectious, their progeny is increasingly ‘neutralized’ by upper respiratory tract (URT)-patrolling migratory dendritic cells (DCs; see Figure below). This can drive the natural selection of highly virulent immune escape lineages because high virulence implies rapid spread from the many virus-loaded migratory DCs to susceptible organ cells (a phenomenon called ‘trans infection’), which is associated with more aggressive replication. In this case, the virus can bypass the need for host mobility (i.e., inter-host transmission) and instead rely on the virus’s ‘mobility’ for inter-organ (i.e., intra-host) transmission.  

In conclusion: Even if high virulence hampers traditional inter-host transmission, evolutionary immune pressure on viral trans infection could favour natural selection of coronavirus strains with higher virulence. This is especially true if intra-host transmission allows the virus to bypass the need for host mobility, as the incapacitation of the host significantly reduces transmission opportunities. This could allow highly virulent coronavirus strains to replicate effectively within hosts, even if the host is severely ill and immobile…

Africa will win…