Strange things are happening on the eve of the tsunami...!

"In many highly COVID-19 vaccinated countries, we're now seeing an interesting new trend: infection rates are going down while death rates are rising. How could this happen?

Remember the key slide * I've been appending to many of my articles.

It explains why enhanced intrinsic infectiousness of the virus results in increased 'neutralization' of progeny virus by DCs, thereby (paradoxically!) mitigating inter-host transmission. Increased adsorption of progeny virus to URT-resident DCs leads to a lower concentration of PNNAbs bound to DC-tethered virions. As this diminishes the virulence-inhibiting capacity of these Abs, C-19 vaccinees become increasingly susceptible to severe disease (i.e., intra-host viral transmission). In other words, diminishing viral infection rates (due to diminished inter-host transmission) eventually drive a higher prevalence of intra-host transmission. The currently observed surge of severe disease cases itself is not alarming, but the signal it sends is, namely that highly C-19 vaccinated" populations are decreasing their PNNAbs and thus more and more vaccinated individuals are left with increasingly less effective protection against viral virulence. Could it be any clearer that this evolution (reduced inter-host spread of the virus accompanied by increased intra-hostdissemination) indicates that these highly vaccinated populations are now exerting an ever higher immune pressure on viral virulence? What else does one need to conclude that a tsunami is on the horizon?"

*(the key slide Geert mentions is explained in great detail in the pinned presentation. The title of that slide is "Low affinity binding of antigenically shifted immunodominant S epitopes by high concentrations of pNabs enables PNNab dependent ADEI")